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The study also revealed that AS-IV could alleviate iron-dependent cell death in cardiomyocytes by activating the Nrf2 signaling pathway and enhancing the expression of GPx4, thereby attenuating oxidative stress induced by DOX (Luo et al., 2021a)

the process involves multiple factors, including an inflammatory factor storm, cell death, the immune response and oxidative stress

[2] It is the main and most common cause of vitamin B 12 deficiency anemia in developed countries, [3] and is characterized by a triad of symptoms: [2] Anemia with bone marrow promegaloblastosis (megaloblastic anemia)

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